Pancreatitis is a medical condition characterized by the inflammation of the pancreas. This condition may appear in two forms: acute and chronic. While acute pancreatitis occurs suddenly and often resolves within a week or two, chronic pancreatitis is a gradual process that worsens over time and requires long-term management.
The most common symptoms of pancreatitis include sudden and intense abdominal pain that radiates to the back, nausea, heaviness in the stomach, digestive difficulties, and vomiting. These symptoms can lead to serious, even life-threatening, complications if not addressed promptly. Therefore, timely diagnosis and treatment are essential.
The diagnosis of pancreatitis primarily relies on the analysis of the symptoms reported by the patient. Blood tests can detect an increase in pancreatic enzymes which, if the pancreatic tissue is damaged, pass into the bloodstream and can be highlighted by these tests. Hyperglycemia, a sign of reduced insulin production, is also common due to the damage to the pancreas.
The diagnostic process for pancreatitis can utilize blood, stool, and instrumental tests. The serum dosage of lipase amylases, for instance, is beneficial in diagnosing pancreatitis due to their characteristic increase under similar circumstances. Other indicators include elevated values of Gamma-GT, serum aspartate transferase or AST, bilirubin, and lactate dehydrogenase.
Moreover, the increase in blood sugar is often a result of pancreatitis, while that of triglyceridemia is more often a contributing cause. A low concentration of the pancreatic enzymes trypsin and chymotrypsin may be seen in the stool.
For a more comprehensive diagnosis, abdominal or endoscopic ultrasound, computed tomography (CT), magnetic resonance imaging, and ERCP (endoscopic retrograde cholangiopancreatography) are also used. These tests provide a more detailed view of the extent of pancreatic damage and can help identify the presence of gallstones.
The treatment for pancreatitis varies depending on whether it is acute or chronic. Acute pancreatitis tends to heal if the cause is removed. The treatment is initially conservative and often requires hospitalization. The first therapeutic interventions aim at resolving the inflammatory process, which essentially involves resting the pancreas by suspending oral feeding for a few days, followed by the slow and gradual reintroduction of food.
Pharmacological treatment focuses on pain control with analgesics and the administration of rehydrating solutions to combat fluid loss caused by vomiting and sweat. In severe cases, antibiotic therapy may be prescribed to prevent infection of the damaged and necrotic pancreatic tissue.
Surgical intervention may be necessary once the inflammation is under control, with the aim of eliminating the cause that triggered the pancreatitis. This can involve removing obstructing stones from the common bile duct or carrying out a subtotal pancreatectomy, which involves the removal of the necrotic section of the pancreas. In cases of stones with the risk of new episodes of obstructive pancreatitis, the gallbladder may be removed.
Lifestyle modifications are crucial, especially in chronic cases where alcohol is the most common causal agent. Abstaining from alcoholic beverages is essential and may require joining special psychotherapeutic groups for alcohol addiction.
In chronic pancreatitis with gland failure, pancreatic extracts (pancreatin) are administered with each meal to allow the normal completion of the digestive processes. A diet low in fat and rich in fresh fruits and vegetables, whole grains, seeds, and lean proteins is recommended. Quitting smoking is equally important in the management of pancreatitis.
Mild forms of acute pancreatitis can regress in a few days, without consequences. However, the more serious and chronic forms may require repeated surgical interventions, aimed at draining the pancreatic duct and removing fragments of damaged tissue.